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Nano-E

Vitamin E antioxidant for horses

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Nano-E vitamin E antioxidant for horses

Nano-E

Vitamin E antioxidant for horses

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Store Locator

Nano-E vitamin E antioxidant for horses

Nano-E

Vitamin E antioxidant for horses

Buy Now Store Locator

Nano-E vitamin E antioxidant for horses

Vitamin E is first and foremost an antioxidant, an agent that keeps free radicals from forming and potentially weakening cells and tissues. In addition to its antioxidant responsibilities, vitamin E is vital to immune, cardiovascular, circulatory, neuromuscular, and reproductive functions.

The availability and necessity of vitamin E in equine diets is well established. When healthy horses are given frequent access to fresh green forage such as good-quality pasture, there is little need for supplementation of vitamin E. However, many horses today are managed without fresh forage in their diets. These horses can survive in such management systems, but they will likely not be consuming sufficient vitamin E for optimal health.

Nano-E® uses advanced nanotechnology to create a rapidly available and absorbed source of vitamin E that enables administration to be timed to provide peak antioxidant protection to performance horses.

Nano-E is a powerful water-soluble liquid vitamin E antioxidant supplement for horses in a unique, rapidly bioavailable form.

Vitamin E is first and foremost an antioxidant, an agent that keeps free radicals from forming and potentially weakening cells and tissues. In addition to its antioxidant responsibilities, vitamin E is vital to immune, cardiovascular, circulatory, neuromuscular, and reproductive functions.

The availability and necessity of vitamin E in equine diets is well established. When healthy horses are given frequent access to fresh green forage such as good-quality pasture, there is little need for supplementation of vitamin E. However, many horses today are managed without fresh forage in their diets. These horses can survive in such management systems, but they will likely not be consuming sufficient vitamin E for optimal health.

Nano-E® uses advanced nanotechnology to create a rapidly available and absorbed source of vitamin E that enables administration to be timed to provide peak antioxidant protection to performance horses.

Nano-E is a powerful water-soluble liquid vitamin E antioxidant supplement for horses in a unique, rapidly bioavailable form.

“I switched Tini over to Nano-E 3 years ago from a powdered vitamin E product. She is on the same dose, but recovers faster from exercise and shows much better muscle tone. I was skeptical about the significance of using a nano-dispersed solution vs powdered natural vitamin E but the improvement was remarkable. It is also extremely palatable; Tini nickers for it when I pull the bottle out!”

– Madelyn Floyd, Three-Day Eventing Rider

Barrel racer Kelley Carrington uses KER products

“My gelding has always shown signs of muscle soreness and had a hard time recovering after stress. Since adding Nano-E to his diet, I have noticed that his back and topline muscles are not sore–he doesn’t cringe when you reach up to touch his back, and he isn’t showing the signs of chronic sore muscles.”

– Kelley Carrington French, Professional Barrel Racer

“He had unexplained, significant back soreness and tightness, and he bucked frequently. After many blood tests and extensive veterinary investigation, it turned out he was completely depleted of vitamin E. Enter Nano-E. He gets it every day and hasn’t had any issues since!”

– Ashley Moore, Grand Prix Dressage Rider

“One of my favorite products from KER is Nano-E. Having a natural-source vitamin E is really important; research has consistently shown that horses get more out of it than the synthetic versions. If you have horses with muscle cramping, sore backs, or tying-up problems, Nano-E should be a crucial part of their diet.”

– Dom Schramm, Upper-level Eventer

Barrel racer Alex Simpson Segyra completing a turn around a barrel on brown horse.

“Nano-E by Kentucky Equine Research has made a world of difference for my mare’s overall health and performance. She went from super irritable (I had the chiropractor on speed dial!) to calm and confident in the warm-up pen, and she’s consistent in her runs. Now I can stretch out her chiro appointments and not feel like she won’t perform because she is muscle sore. This product works!”

– Alex Simpson, Professional Barrel Racer

“Like most performance horses, my horses are not afforded the luxury of lush paddocks all day. To get their much-needed natural vitamin E requirements for muscle and tissue repair, Nano-E is part of my horses’ diets. It helps them recover from the day’s work.”

– Megan Jones, Olympic Medalist

Why should I use Nano-E for my horse?

  • Vitamin E antioxidant supplement for all types of horses
  • Natural-source vitamin E proven more effective than synthetic vitamin E
  • Rapidly available so administration may be timed to provide peak antioxidant protection
  • Reproductive benefits for breeding stallions, and pregnant and lactating broodmares

Research Proven

Research has revealed that vitamin E varies in its potency, based on whether it is natural or synthetic. Controlled studies at Kentucky Equine Research indicate that Nano-E is superior to synthetic and other natural vitamin E sources.

Read the Research

Natural Vitamin E is Preferred

Research has revealed that vitamin E varies in its potency, based on whether it is natural or synthetic. The chemical structures of synthetic and natural vitamin E differ. Controlled studies at Kentucky Equine Research indicate that Nano-E is superior to synthetic and other natural vitamin E sources.

The chemical structures of synthetic and natural vitamin E differ. Natural vitamin E is recognized as d-alpha-tocopherol, and is made up of a single isomer. Synthetic vitamin E, termed dl-alpha tocopherol, contains a mixture of eight different isomers, four tocopherols and four tocotrienols. Of these eight, only one is molecularly equivalent to natural vitamin E. Sources of natural vitamin E, especially Nano-E, more effectively raise serum levels when compared to synthetic, as shown in Figure 1.

Natural vitamin E is recognized as d-alpha-tocopherol, and is made up of a single isomer. Synthetic vitamin E, termed dl-alpha tocopherol, contains a mixture of eight different isomers, four tocopherols and four tocotrienols. Of these eight, only one is molecularly equivalent to natural vitamin E. Sources of natural vitamin E, especially Nano-E, more effectively raise serum levels when compared to synthetic, as shown in Figure 1.

Graph showing change in serum vitamin E in horses given a 5000 IU does of Nano-E vs. synthetic vitamin E

Figure 1. Nano-E, a source of natural vitamin E, more effectively raises serum vitamin E levels when compared to synthetic vitamin E. Dose response equals multiple of 0 hr value which is represented as 1.

Alpha-tocopherol is the form of vitamin E that is most abundant in the body, and is therefore the most appropriate for use in supplementation.

To make alpha-tocopherol stable for use in most supplements, it must be chemically joined with an acid during manufacture, a process called esterification. The acid, in this case acetate, acts as a padlock or protective cap that shields alpha-tocopherol from the damages caused by exposure to oxidative forces. Without esterification, alpha-tocopherol can quickly denature, losing its antioxidant properties and rendering it ineffective.

Once ingested, esterified alpha-tocopherol is subjected to normal digestive enzymes. A certain group of enzymes called esterases are chemically capable of unlocking the padlock created through esterification. Once free, alpha-tocopherol is available for absorption with its antioxidant properties intact.

Fat-soluble vitamins like vitamin E must be offered to horses in a way that maximizes absorption. Because it is not mixed with other ingredients, the vitamin E in Nano-E does not need to be protected by esterification, but it must become water-soluble or dispersible in liquid. This presents a challenge: As everyone knows, oil and water don’t mix.

Researchers developed a method by which fat-soluble vitamins can be absorbed with great efficiency. Because of its oily nature, vitamin E is hydrophobic (water-shunning). To overcome this, researchers use proprietary technology to encapsulate the vitamin E in nanoparticles and then surround each nanoparticle with a hydrophilic (water-loving) outer layer. The hydrophilic outer layer, as illustrated in Figure 2, allows the nanoparticles to be rapidly and evenly released in water-based environments such as the gastrointestinal tract. The differences in bioavailability among vitamin E sources are shown in Figure 3.

Graph showing change in serum vitamin E in horses given a 5000 IU does of Nano-E vs. synthetic vitamin E

Figure 1. Nano-E, a source of natural vitamin E, more effectively raises serum vitamin E levels when compared to synthetic vitamin E. Dose response equals multiple of 0 hr value which is represented as 1.

Alpha-tocopherol is the form of vitamin E that is most abundant in the body, and is therefore the most appropriate for use in supplementation.

To make alpha-tocopherol stable for use in most supplements, it must be chemically joined with an acid during manufacture, a process called esterification. The acid, in this case acetate, acts as a padlock or protective cap that shields alpha-tocopherol from the damages caused by exposure to oxidative forces. Without esterification, alpha-tocopherol can quickly denature, losing its antioxidant properties and rendering it ineffective.

Once ingested, esterified alpha-tocopherol is subjected to normal digestive enzymes. A certain group of enzymes called esterases are chemically capable of unlocking the padlock created through esterification. Once free, alpha-tocopherol is available for absorption with its antioxidant properties intact.

Research Confirms Efficacy

Fat-soluble vitamins like vitamin E must be offered to horses in a way that maximizes absorption. Because it is not mixed with other ingredients, the vitamin E in Nano-E does not need to be protected by esterification, but it must become water-soluble or dispersible in liquid. This presents a challenge: As everyone knows, oil and water don’t mix.

Researchers developed a method by which fat-soluble vitamins can be absorbed with great efficiency. Because of its oily nature, vitamin E is hydrophobic (water-shunning). To overcome this, researchers use proprietary technology to encapsulate the vitamin E in nanoparticles and then surround each nanoparticle with a hydrophilic (water-loving) outer layer. The hydrophilic outer layer, as illustrated in Figure 2, allows the nanoparticles to be rapidly and evenly released in water-based environments such as the gastrointestinal tract. The differences in bioavailability among vitamin E sources are shown in Figure 3.

Graphic showing the liposome encapsulation on Nano-E

Figure 2. Each water-soluble vitamin E nanoparticle in Nano-E is encapsulated or surrounded by liposomes, which allows the nanoparticle to mix evenly throughout a water-based environment such as the gastrointestinal tract.

Graph showing relative bioavailability of Nano-E vs. synthetic, natural acetate, and natural alcohol forms of vitamin E.

Figure 3. Differences in relative bioavailability of various vitamin E sources. Nano-E is more bioavailable than other common sources of vitamin E. Synthetic bioavailability equals 1.

The greatest benefit of this unique delivery system is an increase in the bioavailability of vitamin E. The more vitamin E that is absorbed into the bloodstream, the more available it is for use as a body-wide antioxidant essential for tissue repair and for its imperative roles in various body systems.

Nano-E is recommended for:

  • Race and performance horses in intense work
  • Horses recovering from illness or injury
  • Prior to or following stressful events such as weaning or travel
  • Horses with neurological or neuromuscular disease
  • Horses in confinement or those not receiving fresh green grass

Feeding directions

Daily Use: give 4-8 mL (1000-2000 IU) per 1100 lb (500 kg) horse by mouth or top-dress on feed.
Pre-Competition: give 12-20 mL (3000-5000 IU) per 1100 lb (500 kg) horse 6-12 hours prior to competition or stressful event.

Feeding guidelines for racehorses: Trainers and managers should adhere to the regulations set forth by specific racing jurisdictions prior to using any feed additives or supplements. HISA Compliance

Guaranteed Analysis

250 IU d-alpha-tocopherol per mL

Nano-E is recommended for:

  • Race and performance horses in intense work
  • Horses recovering from illness or injury
  • Prior to or following stressful events such as weaning or travel
  • Horses with neurological or neuromuscular disease
  • Horses in confinement or those not receiving fresh green grass

Feeding directions

Daily Use: give 4-8 mL (1000-2000 IU) per 1100 lb (500 kg) horse by mouth or top-dress on feed.
Pre-Competition: give 12-20 mL (3000-5000 IU) per 1100 lb (500 kg) horse 6-12 hours prior to competition or stressful event.

Feeding guidelines for racehorses: Trainers and managers should adhere to the regulations set forth by specific racing jurisdictions prior to using any feed additives or supplements.

Guaranteed Analysis

250 IU d-alpha-tocopherol per mL

Nano-E vitamin E antioxidant for horses

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Vitamin E antioxidant for horses

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Nano-E vitamin E antioxidant for horses

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