Anti-inflammatory Substance Found in Horse Saliva

Researchers from the University of Calgary and the University of Alberta have discovered that a peptide derived from protein in equine saliva has strong anti-inflammatory properties that could make it the next treatment option for laminitis. Known as phe-glu-gly (phenylalanine-glutamic acid-glycine), or feG, the peptide fits into a new class of anti-inflammatory substances called immune selective anti-inflammatory derivatives (ImSAIDs). As a natural agent, feG is different from steroids and aspirin-like drugs.

Actions of feG include helping to maintain blood pressure, reducing leakage through blood vessel walls, and decreasing tissue damage that can be caused by allergic reactions and white blood cell activity. Laminitis and endotoxemia are two conditions that could be treated with medications that contain feG.