Nano•E® by KERx Special Needs Nutrition is a powerful water-soluble liquid vitamin E antioxidant supplement for horses in a unique, rapidly bioavailable form. Vitamin E is an essential component of body-wide antioxidant defenses and plays a vital role in immune, cardiovascular, circulatory, neuromuscular, and reproductive functions. Vitamin E is recommended for horses without access to fresh green pasture, as well as those with neurological or neuromuscular disease.
Nano•E uses advanced nanotechnology to create a rapidly available and absorbed source of vitamin E that enables administration to be timed to provide peak antioxidant protection to performance horses.
Natural Vitamin E Is Preferred
Research has revealed that vitamin E varies in its potency, based on whether it is natural or synthetic. The chemical structures of synthetic and natural vitamin E differ. Natural vitamin E is recognized as
d-alpha-tocopherol, and is made up of a single isomer. Synthetic vitamin E, termed
dl-alpha tocopherol, contains a mixture of eight different isomers, four tocopherols and four tocotrienols. Of these eight, only one is molecularly equivalent to natural vitamin E. Sources of natural vitamin E, especially Nano•E, more effectively raise serum levels when compared to synthetic, as shown in Figure 1.
Figure 1. Nano•E, a source of natural vitamin E, more effectively raises serum vitamin E levels when compared to synthetic vitamin E. Dose response equals multiple of 0 hr value which is represented as 1.
Alpha-tocopherol is the form of vitamin E that is most abundant in the body, and is therefore the most appropriate for use in supplementation.
To make alpha-tocopherol stable for use in most supplements, it must be chemically joined with an acid during manufacture, a process called esterification. The acid, in this case acetate, acts as a padlock or protective cap that shields alpha-tocopherol from the damages caused by exposure to oxidative forces. Without esterification, alpha-tocopherol can quickly denature, losing its antioxidant properties and rendering it ineffective.
Once ingested, esterified alpha-tocopherol is subjected to normal digestive enzymes. A certain group of enzymes called esterases are chemically capable of unlocking the padlock created through esterification. Once free, alpha-tocopherol is available for absorption with its antioxidant properties intact.
Nano•E provides my three-day event horses with science-based and effective antioxidant protection, and helps my horses recover from muscular effort of the training and competition.
Why should I use Nano•E for my horse?
- Vitamin E antioxidant supplement for all types of horses
- Natural-source vitamin E proven more effective than synthetic vitamin E
- Rapidly available so administration may be timed to provide peak antioxidant protection
- Reproductive benefits for breeding stallions, and pregnant and lactating broodmares
Daily Use: give 4-8 mL (1000-2000 IU) per 1100 lb (500 kg) horse by mouth or top-dress on feed.
Pre-Competition: give 12-20 mL (3000-5000 IU) per 1100 lb (500 kg) horse 6-12 hours prior to competition or stressful event.
Guaranteed Analysis: 250 IU d-alpha-tocopherol per mL
Figure 2. Each water-soluble vitamin E nanoparticle in Nano•E is encapsulated or surrounded by liposomes, which allows the nanoparticle to mix evenly throughout a water-based environment such as the gastrointestinal tract.
Figure 3. Differences in relative bioavailability of various vitamin E sources. Nano•E is more bioavailable than other common sources of vitamin E. Synthetic bioavailability equals 1.
- Race and performance horses in intense work
- Horses recovering from illness or injury
- Prior to or following stressful events such as weaning or travel
- Horses with neurological or neuromuscular disease
- Horses in confinement or those not receiving fresh green grass